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(1996). (1988). (2014). Chronic postweaning lead exposure and response duration performance. Low-level Pb and cardiovascular responses to acute stress in children: the role of cardiac autonomic regulation. BLLs and multiple blood pressure readings were taken at baseline (mean BLL = 8.7 μg/dL) and after a median follow-up time of 5.2 years, at which time the mean BLL had declined to 2.9 μg/dL. Full-scale IQ was assessed using age- and language-appropriate versions of the Wechsler Intelligence Scales for Children. The association for lung cancer remained significant after exclusion of one study that may have been confounded by exposure to arsenic (RR = 1.14, 95% CI = 1.04–1.73). Rosenman, K.D., Sims, A., Luo, Z. and Gardiner, J. Br. Med., 40(1): 99–105. Am. Health Canada (2017). Quintanilla-Vega, B., Smith, D.R., Kahng, M.W., Hernandez, J.M., Albores, A. and Fowler, B.A. In Australia, the National Health and Medical Research Council established a drinking water guideline of 0.01 mg/L (10 µg/L) for lead (NHMRC, 2011). Gulson, B.L., Mahaffey, K.R., Jameson, C.W., Vidal, M., Law, A.J., Mizon, K.J., Smith, A.J. and Lewis, R.J. Krishnan, K. and Carrier, R. (2008). 1-06). (1993). Edwards, M. and Dudi, A. Vaziri, N.D. (2008). This resulted in steady-state BLLs of 11 and 13 μg/dL at 50 and 100 μg/kg bw per day, respectively (unexposed animals had BLLs of 3 μg/dL). OECD/UNEP (1999). Res., 66(1): 12–30. Mov. Health Perspect., 115(11): 1564–1568. (2007). Exposure to lead through diet has been shown to lower cyclic guanosine monophosphate, an important molecule in nitric oxide–mediated vasodilation, in plasma and urine of rats (Khalil-Manesh et al., 1993). Cosmochim. Ophthalmol. Additional epidemiological studies pertaining to environmentally relevant BLLs have focused on creatinine levels exclusively. Manton, W.I., Rothenberg, S.J. (1994). CLAWR is the northern equivalent[further explanation needed] to the United States Air Force's (USAF) Nellis Air Force Range[clarification needed] and provides a different training environment with heavy boreal forest and numerous lakes more closely resembling European terrain. No significant interaction between blood lead and blood cadmium was observed. Br. August 4-6, 2009. Overall, concurrent BLL was most strongly associated with decreases in IQ, and the severity of the effect increased at a higher rate at lower BLLs than at higher BLLs. Source and occurrence of particulate lead in tap water. Health, 50(1): 31–37. Renal adenomas and carcinomas induced in rats after chronic lead exposure, and their relationship with corresponding neoplasia in humans. (2006) study examined a broader BLL range and also as lead exposure–related cancer mortality is unlikely to occur in lower age groups, this study was considered more sensitive than the study by Menke et al. Detection of the mutagenic activity of lead chromate using a battery of microbial tests. Kostial, K., Kello, D. and Jugo, S. (1978). Am. Dietary intakes of contaminants and other chemicals for different age–sex groups of Canadians. Chem. J. J. Ind. (2003) studied renal effects in 4813 hypertensive (mean BLL = 4.21 µg/dL) and 10 398 non-hypertensive (mean BLL = 3.30 µg/dL) adults. Two additional studies have examined the performance of elderly populations on the mini-mental status exam (MMSE). Health, 22(5): 374–380. There are, however, questions surrounding the relevance of renal tumours in humans, considering that only a few studies have established a positive association between lead exposure and renal cancers and that these studies are limited by methodological issues, such as a lack of appropriate exposure monitoring and failure to consider confounding effects (Steenland et al., 1992; Pesch et al., 2000). Am. CPSC (2005). Chronic developmental lead exposure and hippocampal long-term potentiation: biphasic dose–response relationship. Environ. Various neurobehavioural tests pertaining to spatial and non-spatial discrimination as well as fixed-interval testing in which reward for a response was delayed for a specific amount of time were conducted from ages 6 to 9 years. Flora, S.J.S. Total Environ., 171(1–3): 183–187. There is a lack of data to assess the effects of BLLs below 10 µg/dL in experimental animals. Rev., 11(1): 2–22. Prenatal and postnatal oral exposures to lead resulting in BLLs as low as 10 µg/dL have resulted in impaired ability to learn, as shown by poor performance on specific learning tasks, decreased memory, as shown by evasion of repeated stresses, such as shocks to the foot, and altered conduct, including changes in rearing behaviour (Cory-Slechta and Thompson, 1979; Cory-Slechta et al., 1981, 1983, 1985, 2013; Cory-Slechta, 1986; Chen et al., 1997, 2001; Gong and Evans, 1997; Morgan et al., 2000; Stangle et al., 2007). Lead, arsenic and polycyclic aromatic hydrocarbons in soil and house dust in the communities surrounding the Sydney, Nova Scotia, tar ponds. (2010). and Fomon, S.J. Indian J. Med. Variations in the nature of behavioral experience can differentially alter the consequences of developmental exposures to lead, prenatal stress, and the combination. For the most part, the tests were significant for all exposure scenarios (Rice, 1990, 1992b; Rice and Gilbert, 1990a), with one exception for one nonspatial discrimination test in which no effects were observed when exposure occurred in infancy only (Rice and Gilbert, 1990b).

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